AZD-3759
A potent, oral active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR) ; fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue; causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.Lung Cancer Phase 1 Clinical.
Product Specifications
CAS Number
1626387-80-1
Product Name Alternative
AZD-3759
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N1[C@H] (C) CN (C) CC1) OC2=CC3=C (NC4=CC=CC (Cl) =C4F) N=CN=C3C=C2OC
Molecular Formula
C22H23ClFN5O3
Molecular Weight
459.9011
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[ (3-chloro-2-fluorophenyl) amino]-7-methoxy-6-quinazolinyl ester, (2R) -
Available Sizes
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