PFI-2
A first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM; shows high selectivity (>1,000-fold) for SETD7 over 18 other methyltransferases and DNMT1, 500-fold more active than enantiomer (S) -PFI-2; increases YAP nuclear localization, regulates YAP target genes, and phenocopys the effects of Setd7 deficiency on Hippo pathway signaling in murine embryonic fibroblasts.
Product Specifications
CAS Number
1627676-59-8
Product Name Alternative
R) -PFI-2
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1CCN (C1) C (=O) [C@@H] (CC2=CC (=CC=C2) C (F) (F) F) NS (=O) (=O) C3=CC (=C4CNCCC4=C3) F
Molecular Formula
C23H25F4N3O3S
Molecular Weight
499.5215
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-Isoquinolinesulfonamide, 8-fluoro-1,2,3,4-tetrahydro-N-[ (1R) -2-oxo-2- (1-pyrrolidinyl) -1-[[3- (trifluoromethyl) phenyl]methyl]ethyl]-
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