CPI-637
A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM; displays >700-fold selectivity over the BET bromodomains (BRD4 IC50=11.0 uM), also highly selective against other bromodomains; inhibits the expression of MYC with an EC50 of 0.60 uM in a cellular assay. (In Vitro) :CPI-637 (Compound 28) inhibits MYC expression in AMO-1 cells (EC50 value of 0.60 μM) .
Product Specifications
CAS Number
1884712-47-3
Product Name Alternative
CPI637 | CPI 637
Purity
>98% (HPLC)
Solubility
DMSO
Smiles
CN (N=C1C2=CN (C) N=C2) C3=C1C=C (C4=CC=CC (N5) =C4N[C@H] (C) CC5=O) C=C3
Molecular Formula
C22H22N6O
Molecular Weight
386.4497
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3- (1-methyl-1H-pyrazol-4-yl) -1H-indazol-5-yl]-, (4R) -
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