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Ro 48-8071 fumarate

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical

Product Specifications

CAS Number

189197-69-1

Product Name Alternative

Ro-488071 fumarate

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 55 mg/mL

Smiles

O=C (C1=CC=C (OCCCCCCN (CC=C) C) C=C1F) C2=CC=C (Br) C=C2.O=C (O) /C=C/C (O) =O

Molecular Formula

C27H31BrFNO6

Molecular Weight

564.4406

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Methanone, (4-bromophenyl) [2-fluoro-4-[[6- (methyl-2-propen-1-ylamino) hexyl]oxy]phenyl]-, (2E) -2-butenedioate (1:1)

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