Ro 48-8071 fumarate
A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical
Product Specifications
CAS Number
189197-69-1
Product Name Alternative
Ro-488071 fumarate
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 55 mg/mL
Smiles
O=C (C1=CC=C (OCCCCCCN (CC=C) C) C=C1F) C2=CC=C (Br) C=C2.O=C (O) /C=C/C (O) =O
Molecular Formula
C27H31BrFNO6
Molecular Weight
564.4406
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Methanone, (4-bromophenyl) [2-fluoro-4-[[6- (methyl-2-propen-1-ylamino) hexyl]oxy]phenyl]-, (2E) -2-butenedioate (1:1)
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