GSK-6853
A potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1; displays>1600-fold selectivity over others bromodomains (BRPF2/3, BRD4 BD1/BD2) ; displaces NanoLuc-tagged BRPF1 bromodomain from Halo-tagged histone H3.3 (IC50=20 nM) and disrupts chromatin binding in cell assays; demonstrates properties suitable for cellular and in vivo studies.
Product Specifications
CAS Number
1910124-24-1
Product Name Alternative
GSK6853
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 29 mg/mL
Smiles
O=C (NC1=C (N2[C@H] (C) CNCC2) C=C (N3C) C (N (C) C3=O) =C1) C4=CC=CC=C4OC
Molecular Formula
C22H27N5O3
Molecular Weight
409.4815
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[ (2R) -2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-
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