JQEZ-5
A novel potent, selective, SAM-competitive EZH2 inhibitor with IC50 of 80 nM (inhibition of enzymatic function of PRC2) ; demonstrates acutely reduced level of H3K27me3 without affecting mono- and di-methylation, suppresses the proliferation of EZH2-overexpression H661 and H522 cell lines, more effectively than GSK-126 and GSK-343; promotes the regression of EZH2-driven tumors in vivo.
Product Specifications
CAS Number
1913252-04-6
Product Name Alternative
EZ-005 | EZ005 | JQEZ5
Purity
>98% (HPLC)
Solubility
DMSO : 25 mg/mL 46.07 mM; H2O : < 0.1 mg/mL
Smiles
CC (C) N1N=CC2=C (C=C (N=C12) C3=CC=C (N4CCN (CC4) C) N=C3) C (NCC5=C (CCC) C=C (C) NC5=O) =O
Molecular Formula
C30H38N8O2
Molecular Weight
542.688
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[ (6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl) methyl]-6-[6- (4-methylpiperazin-1-yl) pyridin-3-yl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide
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