JQEZ-5
A novel potent, selective, SAM-competitive EZH2 inhibitor with IC50 of 80 nM (inhibition of enzymatic function of PRC2) ; demonstrates acutely reduced level of H3K27me3 without affecting mono- and di-methylation, suppresses the proliferation of EZH2-overexpression H661 and H522 cell lines, more effectively than GSK-126 and GSK-343; promotes the regression of EZH2-driven tumors in vivo.
Product Specifications
CAS Number
1913252-04-6
Product Name Alternative
EZ-005 | EZ005 | JQEZ5
Purity
>98% (HPLC)
Solubility
DMSO : 25 mg/mL 46.07 mM; H2O : < 0.1 mg/mL
Smiles
CC (C) N1N=CC2=C (C=C (N=C12) C3=CC=C (N4CCN (CC4) C) N=C3) C (NCC5=C (CCC) C=C (C) NC5=O) =O
Molecular Formula
C30H38N8O2
Molecular Weight
542.688
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[ (6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl) methyl]-6-[6- (4-methylpiperazin-1-yl) pyridin-3-yl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human Paired mesoderm homeobox protein 1, PRRX1 ELISA Kit
Human Paired mesoderm homeobox protein 1, PRRX1 ELISA Kit
Human Paired mesoderm homeobox protein 1, PRRX1 ELISA Kit
Human Paired mesoderm homeobox protein 1, PRRX1 ELISA Kit
