Tipifarnib
Tipifarnib ((IND 58359, R115777) is a potent and selective inhibitor of FTase (farnesyltransferase) ; inhibits the farnesylation of lamin B and K-RasB peptide substrates with IC50s of 0.86 nM and 7.9 nM, respectively; no activity for PGGT1 (IC50>50 uM) ; shows sensiticity for tumor cell lines bearing H-ras or N-ras mutations; inhibits the growth of tumors bearing mice and orally bioavailable.Blood Cancer Phase 3 Clinical.
Product Specifications
CAS Number
192185-72-1
Product Name Alternative
IND 58359 | R115777 | IND-58359 | IND58359 | R-115777 | R 115777
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1N (C) C2=C (C=C ([C@@] (C3=CC=C (Cl) C=C3) (N) C4=CN=CN4C) C=C2) C (C5=CC=CC (Cl) =C5) =C1
Molecular Formula
C27H22Cl2N4O
Molecular Weight
489.3958
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2 (1H) -Quinolinone, 6-[ (R) -amino (4-chlorophenyl) (1-methyl-1H-imidazol-5-yl) methyl]-4- (3-chlorophenyl) -1-methyl-
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