Lopinavir
Lopinavir (also known as ABT-378) is a highly potent inhibitor of human immunodeficiency virus (HIV) protease that potently inhibits wild-type and mutant HIV protease. (In Vitro) :HIV-1 protease is an essential enzyme for production of mature, infective virus.Lopinavir potently inhibits wild-type and mutant HIV protease (Ki= 1.3 to 3.6 pM), blocks the replication of laboratory and clinical strains of HIV type 1 (EC50=0.006 to 0.017 μM), and maintains high potency against mutant HIV selected by Ritonavir in vivo (EC50=≤0.06 μM) . (In Vivo) :Coadministration with low-dose Ritonavir significantly improves the pharmacokinetic properties and hence the activity of Lopinavir against HIV-1 protease.
Product Specifications
CAS Number
192725-17-0
Product Name Alternative
A-157378.0 | ABT-378
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 126 mg/mL (200.38 mM) ; DMSO: 126 mg/mL (200.38 mM)
Smiles
CC1=C (C (=CC=C1) C) OCC (=O) N[C@@H] (CC2=CC=CC=C2) [C@H] (C[C@H] (CC3=CC=CC=C3) NC (=O) [C@H] (C (C) C) N4CCCNC4=O) O
Molecular Formula
C37H48N4O5
Molecular Weight
628.8
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2S) -N-[ (2S,4S,5S) -5-[[2- (2,6-dimethylphenoxy) acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2- (2-oxo-1,3-diazinan-1-yl) butanamide
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