Cardamonin?
Cardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. Cardamonin does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. Cardamonin suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
Product Specifications
CAS Number
19309-14-9
Product Name Alternative
Alpinetin chalcone | Cardamomin
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
O=C (C1=C (OC) C=C (O) C=C1O) /C=C/C2=CC=CC=C2
Molecular Formula
C16H14O4
Molecular Weight
270.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2',4'-Dihydroxy-6'-methoxychalcone
Available Sizes
Frequently Asked Questions
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