SB 239063
A potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β; shows no activity (>100 μM) against the γ- and δ-kinase isoforms, and a panel of protein kinase; inhibits IL-1 and TNF-alpha production in LPS-stimulated human PBMCs (IC50= 0.12 and 0.35 uM) ; reduces inflammatory cytokine production, airways eosinophil infiltration and persistence in vivo.
Product Specifications
CAS Number
193551-21-2
Product Name Alternative
SB-239063 | SB239063
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O[C@H]1CC[C@H] (N2C (C3=NC (OC) =NC=C3) =C (C4=CC=C (F) C=C4) N=C2) CC1
Molecular Formula
C20H21FN4O2
Molecular Weight
368.4048
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclohexanol, 4-[4- (4-fluorophenyl) -5- (2-methoxy-4-pyrimidinyl) -1H-imidazol-1-yl]-, trans-
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