YU 238259
YU 238259 is a novel DNA double-strand break repair inhibitor that exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects; specifically inhibits homology-dependent DNA repair (HDR), but not non-homologous end-joining (NHEJ), in cell-based GFP reporter assays; significantly delays tumor growth of BRCA2-deficient human tumor xenografts in nude mice.
Product Specifications
CAS Number
1943733-16-1
Product Name Alternative
YU238259
Purity
>98% (HPLC)
Solubility
DMSO: 84 mg/mL (182.6 mM) ; Ethanol: <1 mg/mL; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
C1=CC (OC) =CC=C1S (=O) (=O) NCC1=CC=C (C (=O) NCCC2=CC=C (Cl) C=N2) C=C1
Molecular Formula
C22H22ClN3O4S
Molecular Weight
459.95
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[2- (5-Chloro-2-pyridinyl) ethyl]-4-[[[ (4-methoxyphenyl) sulfonyl]amino]methyl]benzamide
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