Galanthamine HBr

Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase (AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. (In Vitro) :Galanthamine hydrobromide is 53-fold selectivity for AChE over butyrylcholinesterase.Galanthamine hydrobromide (25-1000 μM) inhibits both Aβ 1-40 (50 μM) and Aβ 1-42 (50 μM) aggregation.Galanthamine hydrobromide (25-1000 μM) protects against Aβ (1-40) and Aβ (1-42) toxicity in SH-SY5Y cells.Galanthamine hydrobromide also dramatically reduces Aβ (1-40) -induced cellular apoptosis. (In Vivo) :Galanthamine hydrobromide (1.25-2.5 mg/kg; i.p.) reduces cognitive deficits in APP23 mice.Galanthamine hydrobromide (10 mg/kg; i.g.) displays short elimination half-life of approximately 2 h in wild-type mice.