KYA-1797K
A derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling; dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation with IC50 of 0.75 uM; more effectively reduces the levels of both β-catenin and pan-Ras as well as the activities of ERK and Akt in SW480 cells; binds to Axin (Kd to WT axin-RGS=0.29 uM) and destabilizes b-catenin and Ras; inhibits growth of CRC cells with GI50 of 4-5 uM; suppresses the tumors induced by APC and KRAS mutations in tumor xenograft mice (25 mg/kg, i.p.) .
Product Specifications
CAS Number
1956356-56-1
Product Name Alternative
KYA 1797K
Purity
>98% (HPLC)
Solubility
Ethanol: <1 mg/mL; DMSO: 20 mg/mL (45.2 mM) ; Water: 20 mg/mL (45.2 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C ([O-]) CCN (C/1=O) C (SC1=C/C2=CC=C (C3=CC=C ([N+] ([O-]) =O) C=C3) O2) =S.[K+]
Molecular Formula
C17H11KN2O6S2
Molecular Weight
442.501
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Potassium (Z) -3- (5- ((5- (4-nitrophenyl) furan-2-yl) methylene) -4-oxo-2-thioxothiazolidin-3-yl) propanoate
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