Mesna
Mesna (Uromitexan, Mesnex), a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (In Vitro) :Mesna (1-1000 μM) reduces H2O2, HOCl and OH concentrations in a dose-dependent manner, with an IC50 of 32, 21, and 305 μM, respectively in cell-free experiments. (In Vivo) :Mesna (150 mg/kg; a single i.p.) protects the rat brain against traumatic injury.Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats.
Product Specifications
CAS Number
19767-45-4
Product Name Alternative
Coenzyme M | HS-CoM | 2-Mercaptoethanesulfonate | UCB 3983
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 7 mg/mL (42.63 mM) ; DMSO: 33 mg/mL (200.99 mM)
Smiles
SCCS (=O) ([O-]) =O.[Na+]
Molecular Formula
C2H5NaO3S2
Molecular Weight
164.18
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Sodium 2-mercaptoethanesulfonate
Available Sizes
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