Parecoxib
A potent and selective COX-2 inhibitor; a water-soluble prodrug of valdecoxib.Pain Approved (In Vitro) :Parecoxib (0-200 μM; 24-48 hours) inhibits the cell proliferation of GBM cells in a dose-dependent manner in GBM cells.Parecoxib (200 μM; 24-48 hours) results in a decreasee migratory ability of U343 cells than PBS-treated group. (In Vivo) :Parecoxib (intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days) does not affect locomotor activity in the elevated plus-maze test, and Parecoxib at 5 and 10 mg/kg shows higher levels of percentage of time spent in the open arms.
Product Specifications
CAS Number
198470-84-7
Product Name Alternative
SC-69124
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CCC (=O) NS (=O) (=O) C1=CC=C (C=C1) C1=C (C) ON=C1C1=CC=CC=C1
Molecular Formula
C19H18N2O4S
Molecular Weight
370.4222
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Propanamide, N-[[4- (5-methyl-3-phenyl-4-isoxazolyl) phenyl]sulfonyl]-
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