ML364
A potent, selective, reversible deubiquitinase USP2 inhibitor with IC50 of 1.1 uM in biochemical assay; also inhibits USP8 (IC50=0.95 uM), shows no against caspase 6/7, MMP1, MMP9 and USP15 and a panel of 102 kinase; increases cellular cyclin D1 degradation and causes cell cycle arrest and shows antiproliferative in cancer cell lines; also decreases homologous recombination-mediated DNA repair.
Product Specifications
CAS Number
1991986-30-1
Product Name Alternative
ML 364 | ML-364
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
O=C (NC1=NC (C2=CC=CC=C2) =CS1) C3=CC=C (C (F) (F) F) C=C3NS (=O) (C4=CC=C (C) C=C4) =O
Molecular Formula
C24H18F3N3O3S2
Molecular Weight
517.5432296
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 2-[[ (4-methylphenyl) sulfonyl]amino]-N- (4-phenyl-2-thiazolyl) -4- (trifluoromethyl) -
Available Sizes
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