APS-2-79 hydrochloride
A small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM) ; binds to the KSR2-MEK1 complex and impedes the assembly of RAF–KSR–MEK complexes, suppresses KSR-stimulated MEK and ERK phosphorylation and suppresses oncogenic Ras mutations; enhances the efficacy of Trametinib against cancer cell lines containing K-Ras mutations.
Product Specifications
CAS Number
2002381-31-7
Product Name Alternative
APS 2-79 hydrochloride
Purity
>98% (HPLC)
Solubility
DMSO
Smiles
CC1=CC (OC2=CC=CC=C2) =CC=C1NC3=C4C=C (OC) C (OC) =CC4=NC=N3.[H]Cl
Molecular Formula
C23H22ClN3O3
Molecular Weight
423.89208
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Quinazolinamine, 6,7-dimethoxy-N- (2-methyl-4-phenoxyphenyl) -, hydrochloride (1:1)
Available Sizes
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