GNE-6776
GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM ; dislpalys selectivity over USP47 and USP5 (>200 uM) ; promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents; promotes on-target pathway modulation in human xenografts.
Product Specifications
CAS Number
2009273-71-4
Product Name Alternative
GNE6776 | GNE 6776
Purity
>98% (HPLC)
Solubility
DMSO: ≥310 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CCC1=C (C (=NC=C1C2=CN=C (C=C2) C (=O) NC) N) C3=CC=C (C=C3) O
Molecular Formula
C20H20N4O2
Molecular Weight
348.406
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-[6-Amino-4-ethyl-5- (4-hydroxyphenyl) -3-pyridyl]-N-methyl-pyridine-2carboxamide
Available Sizes
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