WNK463
The first, potent, selective, and orally bioavailable pan With-No-Lysine (WNK) Kinase catalytic activity inhibitor with IC50 of 5/1/6/9 nM for WNK1/2/3/4, respectively; shows >50% inhibition against only 2 out of 442 human kinases at 10 uM; affects blood pressure and body fluid and electro-lyte homeostasis in rodent models of hypertension.
Product Specifications
CAS Number
2012607-27-9
Product Name Alternative
WNK-463 | WNK 463
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
O=C (C1=CN=CN1C2CCN (C3=NC=C (C4=NN=C (C (F) (F) F) O4) C=C3) CC2) NC (C) (C) C
Molecular Formula
C21H24F3N7O2
Molecular Weight
463.4562
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Imidazole-5-carboxamide, N- (1,1-dimethylethyl) -1-[1-[5-[5- (trifluoromethyl) -1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-
Available Sizes
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