JQ-1 carboxylic acid
JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones; a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
Product Specifications
CAS Number
202592-23-2
Product Name Alternative
+) -JQ-1 carboxylic acid
Purity
>98% (HPLC)
Solubility
DMSO
Smiles
O=C (O) C[C@H]1C2=NN=C (C) N2C3=C (C (C) =C (C) S3) C (C4=CC=C (Cl) C=C4) =N1
Molecular Formula
C19H17ClN4O2S
Molecular Weight
400.8819
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4- (4-chlorophenyl) -2,3,9-trimethyl-, (6S) -
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Micronic TPE Capcluster-96 mat, gray, 96 caps/mat, 10 mats/pack (960 caps)
KIR2DL4 (CD158D, KIR103AS, Killer Cell Immunoglobulin-like Receptor 2DL4, CD158 Antigen-like Family Member D, G9P, Killer Cell Inhibitory Receptor 103AS, MHC Class I NK Cell Receptor KIR103AS, CD158d) (MaxLight 405)
KIR2DL4 (CD158D, KIR103AS, Killer Cell Immunoglobulin-like Receptor 2DL4, CD158 Antigen-like Family Member D, G9P, Killer Cell Inhibitory Receptor 103AS, MHC Class I NK Cell Receptor KIR103AS, CD158d) (MaxLight 405)
ERBB2IP (ERBIN, Protein LAP2, Densin-180-like Protein, Erbb2-interacting Protein, KIAA1225, LAP2) (MaxLight 650)
