AMI-1
A specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases; inhibits PRMT1 and Hmt1p with IC50s of 8.81 uM and 3.03 uM respectively; increases the ratio of Bax/Bcl-2, and leads to apoptosis and loss of migratory activity in several HCC cells, decreases the expression levels of H4R3me2s; strongly inhibits HCC growth in vivo.
Product Specifications
CAS Number
20324-87-2
Product Name Alternative
AMI-1 | AMI 1 | AMI1 | AMI-1 disodium salt.
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
O=C (NC1=CC2=CC (S (=O) ([O-]) =O) =CC (O) =C2C=C1) NC3=CC4=CC (S (=O) ([O-]) =O) =CC (O) =C4C=C3.[Na+].[Na+]
Molecular Formula
C21H14N2Na2O9S2
Molecular Weight
548.4534
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Naphthalenesulfonic acid, 7,7'- (carbonyldiimino) bis[4-hydroxy-, sodium salt (1:2)
Available Sizes
Frequently Asked Questions
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500 mL Single-Use Storage Bottle (NG)