WM-1119
WM-1119 (WM1119) is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with Kd of 2 nM, shows greate bioavailability and specificity for KAT6A than WM-8014; displays 1,100-fold and 250-fold selectivity over KAT5 and KAT7, respectively; causes cell cycle arrest in G1 and senescence phenotype similar to WM-8014; demonstrates growth inhibition assays in lymphoma cell line EMRK1184 (IC50=0.25 uM, 10-fold potency than WM-8014), increases levels of Cdkn2a and Cdkn2b mRNA and p16INK4a and p19ARF protein, as well as a delayed increase in Cdkn1a mRNA; arrests lymphoma growth in vivo without effect on haematocrit, erythrocytes or platelet numbers.
Product Specifications
CAS Number
2055397-28-7
Product Name Alternative
WM1119 | WM 1119
Purity
>98% (HPLC)
Solubility
DMSO: ≥150 mg/mL (385.23 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NNS (=O) (C1=CC=CC=C1F) =O) C2=CC (C3=NC=CC=C3) =CC (F) =C2
Molecular Formula
C18H13F2N3O3S
Molecular Weight
389.377
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzoic acid, 3-fluoro-5- (2-pyridinyl) -, 2-[ (2-fluorophenyl) sulfonyl]hydrazide
Available Sizes
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