Calycosin-7-O-beta-D-glucoside

Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycosin 7-O-β-D-glucoside is anticipated to be a promising anti-HIV agent. It shows scavenging activity to DPPH radicals, and superoxide anion . Calycosin 7-O-β-D-glucopyranoside possesses an alleviating effect on osteoarthritis and can increase the fluidity of brain cell membrane in ischemia-reperfusion rats. Calycosin 7-O-β-D-glucopyranoside possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. (In Vitro) :Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex. (In Vivo) :Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model.