Mitiglinide calcium hydrate

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells; has potent hypoglycemic effects.Diabetes Approved (In Vitro) :Mitiglinide calcium hydrate inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells. (In Vivo) :Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load.