ZM 336372

ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2; suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells, with marked induction of the cell cycle inhibitors p21 and p18; blocks cellular proliferation and suppresses NE vasoactive peptide production in pheochromocytoma cells.