ZM 336372
ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2; suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells, with marked induction of the cell cycle inhibitors p21 and p18; blocks cellular proliferation and suppresses NE vasoactive peptide production in pheochromocytoma cells.
Product Specifications
CAS Number
208260-29-1
Product Name Alternative
ZM336372 | ZM-336372
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=C (C) C (NC (C2=CC=C (O) C=C2) =O) =C1) C3=CC=CC (N (C) C) =C3
Molecular Formula
C23H23N3O3
Molecular Weight
389.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 3- (dimethylamino) -N-[3-[ (4-hydroxybenzoyl) amino]-4-methylphenyl]-
Available Sizes
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