LYN-1604
LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells), displays a good effect on ULK1 activation with an EC50 of 18.94 nM; induces cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells; induces cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis; inhibits the growth of xenograft TNBC.
Product Specifications
CAS Number
2088939-99-3
Product Name Alternative
LYN1604
Field of Research
Signal Transduction
Purity
>98% (HPLC)
Solubility
DMSO: 46 mg/mL (78.7 mM) ; Water: 90 mg/mL (153.9 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CC (C) CN (CC (C) C) CC (=O) N1CCN (CC1) CC (C2=C (C=C (C=C2) Cl) Cl) OCC3=CC4=CC=CC=C4C=C3
Molecular Formula
C33H43Cl2N3O2
Molecular Weight
584.626
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethanone, 2-[bis (2-methylpropyl) amino]-1-[4-[2- (2,4-dichlorophenyl) -2- (2-naphthalenylmethoxy) ethyl]-1-piperazinyl]-
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