VX-745
A potent and selective p38α kinase inhibitor with IC50 of 9 nM; shows 20-fold selectivity for p38α over p38β (Ki=220 nM) and no significant inhibition for MAP kinases (with the exception of MKK6) ; exhibits inhibition of PBMC IL-1β and TNFα IC50 of 45 and 51 nM, respectively; possesses favorable PK profile, and demonstrates good in vivo activity in models of inflammation.Alzheimer's Disease Phase 2 Clinical.
Product Specifications
CAS Number
209410-46-8
Product Name Alternative
VX 745 | VX745 | Neflamapimod
Purity
>98% (HPLC)
Solubility
DMSO: 13.08 mg/mL (Need ultrasonic)
Smiles
O=C1C (C2=C (Cl) C=CC=C2Cl) =C3C=CC (SC4=CC=C (F) C=C4F) =NN3C=N1
Molecular Formula
C19H9Cl2F2N3OS
Molecular Weight
436.2621
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6H-Pyrimido[1,6-b]pyridazin-6-one, 5- (2,6-dichlorophenyl) -2-[ (2,4-difluorophenyl) thio]-
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