SEL-201
SEL-201 (SLV-2436, SEL201-88) is a novel potent, selective, ATP-competitive and oral MNK1/2 inhibitor with IC5010.8/5.4 nM, respectively; displays acceptable kinome selectivity in the broad KINOMEscan (450 distinct kinases) ; potently suppresses MNK1/2 activity in a panel of KIT-mutant melanoma cell lines, reduces clonogenicity, migration, and lung metastasis of KIT-mutant melanoma cells both in vitro and in vivo.
Product Specifications
CAS Number
2095704-43-9
Product Name Alternative
SLV-2436 | SEL201-88
Purity
>98% (HPLC)
Solubility
< 1 mg/ml refers to the product slightly soluble or insoluble
Smiles
C1=CC (=CC (=C1) Cl) CN2C=C (C=CC2=O) C3=CC4=C (C=C3) C (=NN4) N
Molecular Formula
C19H15ClN4O
Molecular Weight
350.806
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- (3-amino-1H-indazol-6-yl) -1-[ (3-chlorophenyl) methyl]-1,2-dihydropyridin-2-one
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