MCC950
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3; blocks NLRP3 induced ASC oligomerization, does not block K+ efflux, Ca2+ flux or NLRP3-ASC interactions; reduces interleukin-1β (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), rescues neonatal lethality in mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.
Product Specifications
CAS Number
210826-40-7
Product Name Alternative
MCC-950 | CP-456773
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 28 mg/mL
Smiles
CC (C) (C1=COC (=C1) S (=O) (=O) NC (=O) NC2=C3CCCC3=CC4=C2CCC4) O
Molecular Formula
C20H24N2O5S
Molecular Weight
404.4799
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Furansulfonamide, N-[[ (1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-4- (1-hydroxy-1-methylethyl) -
Available Sizes
Explore Other Products
Browse additional items from our catalog
Myeloid Differentiation Factor 88 (MyD88) Magnetic Luminex Assay Kit
Biotin-Linked Anti-Prostatic Acid Phosphatase (PAP)
Biotin-Linked Anti-Prostatic Acid Phosphatase (PAP)