FL-411
FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells; induces ACD pathways involved in HMGB1, VDAC1/2, and eEF2, displays a therapeutic potential on both breast cancer xenograft mouse and zebrafish models.
Product Specifications
CAS Number
2118944-88-8
Product Name Alternative
FL411
Purity
>98% (HPLC)
Solubility
< 1 mg/ml refers to the product slightly soluble or insoluble
Smiles
CC1=CC (=CC (=C1O) C) C2=NC3=C (C4=C (S3) CN (CC4) C) C (=O) N2
Molecular Formula
C18H19N3O2S
Molecular Weight
341.429
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (4-Hydroxy-3,5-dimethylphenyl) -7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4 (3H) -one
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