Dabigatran
A reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM; an anticoagulant agent used to prevent stroke with atrial fibrillation.Thrombosis Approved (In Vitro) :Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively. (In Vivo) :Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model.
Product Specifications
CAS Number
211914-51-1
Product Name Alternative
BIBR 953 | BIBR 953ZW | BIBR953 | BIB-953
Purity
>98% (HPLC)
Solubility
DMSO: < 1 mg/mL; H2O: < 1 mg/mL
Smiles
CN1C2=C (C=C (C=C2) C (=O) N (CCC (=O) O) C3=CC=CC=N3) N=C1CNC4=CC=C (C=C4) C (=N) N
Molecular Formula
C25H25N7O3
Molecular Weight
471.5111
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
β-Alanine, N-[[2-[[[4- (aminoiminomethyl) phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-
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