WNK inhibitor 11
WNK inhibitor 11 is a potent, selectiive and orally active inhibitor of WNK1 kinase with IC50 of 6 nM, 1,000-fold selectivity over WNK4 and 57-fold selectivity over WNK2; shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and FER kinase; reduces blood pressure in mice overexpressing human WNK1, and induced diuresis, natriuresis and kaliuresis in spontaneously hypertensive rats.
Product Specifications
CAS Number
2123489-30-3
Product Name Alternative
WNK-IN-11 | WNK IN 11 | WNKIN11 | WNK inhibitor 11 | WNK inhibitor-11 |
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : 150 mg/mL 324.39 mM; H2O : < 0.1 mg/mL
Smiles
O=C (C1=CC (C2=CSC (NC) =N2) =NC=C1Cl) N3CCN (CC4=CC=C (Cl) C=C4) CC3
Molecular Formula
C21H21Cl2N5OS
Molecular Weight
462.393
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(5-chloro-2- (2- (methylamino) thiazol-4-yl) pyridin-4-yl) (4- (4-chlorobenzyl) piperazin-1-yl) methanone
Available Sizes
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