BI-3802
BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM; inhibits the BCL6/Co-repressor complex formation with IC50 of 43 nM in vitro, also is a potent and efficacious degrader of the BCL6 protein in many DLBCL cell lines (DC50=20 nM in SU-DHL-4 cells) ; BI-3802 is a valuable probe compound for testing hypotheses around BCL6 biology.
Product Specifications
CAS Number
2166387-65-9
Product Name Alternative
BI3802 | BI 3802
Purity
>98% (HPLC)
Solubility
DMSO : 5 mg/mL 10.31 mM; Methanol : 2 mg/mL 4.12 mM; H2O : < 0.1 mg/mL
Smiles
O=C (NC) COC1=CC2=C (N (C) C1=O) C=CC (NC3=NC (N4C[C@@H] (C) C[C@@H] (C) C4) =NC=C3Cl) =C2
Molecular Formula
C24H29ClN6O3
Molecular Weight
484.985
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((6- ((5-chloro-2- ((3S,5R) -3,5-dimethylpiperidin-1-yl) pyrimidin-4-yl) amino) -1-methyl-2-oxo-1,2-dihydroquinolin-3-yl) oxy) -N-methylacetamide
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