Fludarabine
Fludarabine (NSC 118218), a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies. (In Vitro) :Fludarabine (5 μM; 48 hours) induces a decrease in p27kip1 expression. (In Vivo) :Fludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD.
Product Specifications
CAS Number
21679-14-1
Product Name Alternative
F-ara-A | NSC 118218
Purity
>98% (HPLC)
Solubility
DMSO: 57 mg/mL (199.83 mM)
Smiles
NC1=C2N=CN ([C@H]3[C@H] ([C@@H] ([C@@H] (CO) O3) O) O) C2=NC (F) =N1
Molecular Formula
C10H12FN5O4
Molecular Weight
285.23
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2R,3S,4S,5R) -2- (6-amino-2-fluoro-9H-purin-9-yl) -5- (hydroxymethyl) tetrahydrofuran-3,4-diol
Available Sizes
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