YKL 06-061
YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively; inhibits only one kinase FRK (IC50=1.1 nM), more strongly than SIKs, in a panel of 468 human kinases; dose-dependently increases MITF mRNA expression in human melanoma cells; induces significant pigmentation in Mc1r-deficient mice and normal human skin.
Product Specifications
CAS Number
2172617-15-9
Product Name Alternative
YKL06-061
Purity
>98% (HPLC)
Solubility
DMSO : 62.5 mg/mL 118.45 mM; H2O : < 0.1 mg/mL
Smiles
O=C1N (C2CCC2) C3=NC (NC4=CC=C (N5CCN (C) CC5) C=C4OC) =NC=C3CN1C6=C (C) C=CC=C6C
Molecular Formula
C30H37N7O2
Molecular Weight
527.673
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Pyrimido[4,5-d]pyrimidin-2 (1H) -one,1-cyclobutyl-3- (2,6-dimethylphenyl) -3,4-dihydro-7-[[2-methoxy-4- (4-methyl-1-piperazinyl) phenyl]amino]-
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