LIT-927
LIT-927 (LIT927) is the first selective, locally and orally active CXCL12 neutraligand with Ki of 267 nM for CXCL12-TR binding inhibition; displays excellent selectivity over other chemokines (CCL17, CCL22, CCL5 and CCL2), inhibits the increase in intracellular calcium concentration in EGFP-CXCR4+HEK cells in response to CXCL12 at 10 uM, has no effect on calcium responses triggered by either CCL17 or CCL22 on EGFP-CCR4+HEK cells, CCL5 on EGFP-CCR5+ HEK cells, or by CCL2 on EGFP-CCR2+HEK cells; reduces eosinophil recruitment in murine model of allergic airway hypereosinophilia.
Product Specifications
CAS Number
2172879-52-4
Product Name Alternative
LIT927
Purity
>98% (HPLC)
Solubility
DMSO: 25 mg/mL, 76.05 mM; Water: Insoluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C1N=C (C2=CC=C (Cl) C=C2) C=C (C3=CC=C (O) C (OC) =C3) N1
Molecular Formula
C17H13ClN2O3
Molecular Weight
328.752
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (4-Chlorophenyl) -6- (4-hydroxy-3-methoxyphenyl) pyrimidin-2 (1H) -one
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