L-Menthol

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (-) -menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. . (In Vitro) : (-) -Menthol (Menthol) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25 (OH) 2D3-mediated growth inhibition in LNCaP cells. At high (-) -Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish. (-) -Menthol (0.8 mM) can increase [Ca2+]i via transmembrane influx or store release pathways. Peak increase in [Ca2+]i was 102.3±39 nM (n=3) in (-) -Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25 (OH) 2D3 with (-) -Menthol, respectively.Combination of 1α,25 (OH) 2D3 with (-) -Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression.