Rosuvastatin
A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM; potently inhibits cholesterol biosynthesis (IC50=1.12 nM) in rat isolated hepatocytes, 100 times more potent than pravastatin; also exerts important anti-inflammatory effects via inhibition of endothelial cell adhesion molecule expression.Dyslipidemia Approved (In Vivo) :Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin.
Product Specifications
CAS Number
287714-41-4
Product Name Alternative
ZD-4522
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) C1=NC (=NC (=C1/C=C/[C@H] (C[C@H] (CC (=O) O) O) O) C2=CC=C (C=C2) F) N (C) S (=O) (=O) C
Molecular Formula
C22H28FN3O6S
Molecular Weight
481.5376
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-Heptenoic acid, 7-[4- (4-fluorophenyl) -6- (1-methylethyl) -2-[methyl (methylsulfonyl) amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E) -
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