Cediranib
A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively; also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR; inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells; inhibits angiogenesis, neovascular survival and tumor growth in vivo. Ovarian Cancer Phase 3 Clinical.
Product Specifications
CAS Number
288383-20-0
Product Name Alternative
AZD2171 | AZD 2171 | AZD-2171
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 49 mg/mL
Smiles
COC1=C (OCCCN2CCCC2) C=C2N=CN=C (OC3=C (F) C4=C (NC (C) =C4) C=C3) C2=C1
Molecular Formula
C25H27FN4O3
Molecular Weight
450.5053
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinazoline, 4-[ (4-fluoro-2-methyl-1H-indol-5-yl) oxy]-6-methoxy-7-[3- (1-pyrrolidinyl) propoxy]-
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