Canertinib dihydrochloride
A potent, irreversible, orally available pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 7.5 nM and 9.0 nM in autophosphorylation assay; displays no activity to PDGFR, FGFR, InsR, PKC, and CDK1/2/4; suppresses heregulin-stimulated tyrosine phosphorylation of erbB2, erbB3 and erbB4 with IC50 of 5, 14 and 10 nM, respectively, also inhibits expression of pp62c-fos in response to heregulin; shows high in vivo activity against A431 xenografts.Lung Cancer Discontinued.
Product Specifications
CAS Number
289499-45-2
Product Name Alternative
Canertinib | CI-1033 dihydrochloride | PD-183805 dihydrochloride | CI1033 dihydrochloride
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C=CC (=O) NC1=C (C=C2C (=C1) C (=NC=N2) NC3=CC (=C (C=C3) F) Cl) OCCCN4CCOCC4.Cl.Cl
Molecular Formula
C24H27Cl3FN5O3
Molecular Weight
558.8603
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propenamide, N-[4-[ (3-chloro-4-fluorophenyl) amino]-7-[3- (4-morpholinyl) propoxy]-6-quinazolinyl]-, hydrochloride (1:2)
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