T0901317
A potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively) ; upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism; decreases amyloid-β production in primary neurons in vitro; displays an EC50 of ~ 5 μM for activation of FXRs.Alzheimer's Disease Discontinued.
Product Specifications
CAS Number
293754-55-9
Product Name Alternative
T 0901317 | T-0901317
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 27 mg/mL
Smiles
OC (C (F) (F) F) (C (F) (F) F) C1=CC=C (N (CC (F) (F) F) S (C2=CC=CC=C2) (=O) =O) C=C1
Molecular Formula
C17H12F9NO3S
Molecular Weight
481.3327
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenesulfonamide, N- (2,2,2-trifluoroethyl) -N-[4-[2,2,2-trifluoro-1-hydroxy-1- (trifluoromethyl) ethyl]phenyl]-
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