CIL-56
YAP1 inhibitor CA3 (CA3; CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/Tead transcriptional activity; also demonstrates strong inhibitory effects on esophageal adenocarcinoma cell growth especially on YAP1 high-expressing esophageal adenocarcinoma cells both in vitro and in vivo; can effectively suppress radiation-resistant cancer stem cell (CSC) properties and aggressive phenotype by inhibiting proliferation, inducing apoptosis, reducing tumor sphere formation; synergistically inhibits cancer cell growth combined with 5-FU; triggers nonapoptotic cell death, a potent and selective probe of ferroptosis; stimulates the activity of ACC1, inhibits the normal breakdown of fatty acids by mitochondrial β-oxidation.
Product Specifications
CAS Number
300802-28-2
Product Name Alternative
YAP1 inhibitor CA3
Purity
>98% (HPLC)
Solubility
DMSO: 88 mg/mL (179.7 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=S (C1=CC2=C (C=C1) C3=C (C=C (S (=O) (N4CCCCC4) =O) C=C3) /C2=N\O) (N5CCCCC5) =O
Molecular Formula
C23H27N3O5S2
Molecular Weight
489.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,7-bis (piperidin-1-ylsulfonyl) -9H-fluoren-9-one oxime
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