BH3I-1
A small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay; specifically blocks the BH3-domain-mediated heterodimerization between Bcl-2 family members in vitro and in vivo and induces apoptosis; also potently inhibits p53/hDM2 with Kd of 5.3 uM.
Product Specifications
CAS Number
300817-68-9
Product Name Alternative
BHI1 | BHI-1 | BHI 1 | BH 3I1
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 3.9 mg/mL
Smiles
O=C (O) C (C (C) C) N (C/1=O) C (SC1=C\C2=CC=C (Br) C=C2) =S
Molecular Formula
C15H14BrNO3S2
Molecular Weight
400.3105
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Thiazolidineacetic acid, 5-[ (4-bromophenyl) methylene]-α- (1-methylethyl) -4-oxo-2-thioxo-
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