CID5721353
BCL6 inhibitor 79-6 (Compound 79-6) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM; binds to a pocket in the lateral groove of the BCL6 BTB domain, specifically inhibits BCL6 but not other BTB-ZF proteins; disrupts BCL6/corepressor complexes and reactivates BCL6 target genes in vitro and in vivo, selectively kills BCL6-dependent DLBCL cells; suppresses human DLBCL xenografts in mice with favorable pharmacokinetics.
Product Specifications
CAS Number
301356-95-6
Product Name Alternative
CID5721353 | CID-5721353 | CID 5721353 | BCL6 Inhibitor
Purity
>98% (HPLC)
Solubility
< 1 mg/ml refers to the product slightly soluble or insoluble
Smiles
O=C (O) C (N (C/1=O) C (SC1=C2C (NC3=C/2C=C (Br) C=C3) =O) =S) CC (O) =O
Molecular Formula
C15H9BrN2O6S2
Molecular Weight
457.269
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(Z) -2- (5- (5-bromo-2-oxoindolin-3-ylidene) -4-oxo-2-thioxothiazolidin-3-yl) succinic acid
Available Sizes
Frequently Asked Questions
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