D4476
D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro; slightly weaker for ALK5 inhibition (IC50=0.5 uM) ; weak activity for p38α MAPK and no activity for PKB, SGK; specifically inhibits the phosphorylation of endogenous FOXO1a on Ser322 and Ser325; more potent and specific than IC261 or CKI-7.
Product Specifications
CAS Number
301836-43-1
Product Name Alternative
Casein Kinase I Inhibitor | D 4476 | D-4476
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N) C1=CC=C (C2=NC (C3=CC=C (OCCO4) C4=C3) =C (C5=NC=CC=C5) N2) C=C1
Molecular Formula
C23H18N4O3
Molecular Weight
398.414
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 4-[4- (2,3-dihydro-1,4-benzodioxin-6-yl) -5- (2-pyridinyl) -1H-imidazol-2-yl]-
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