Ciliobrevin A
A small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su (fu) to modulate Gli processing, activation or trafficking; does not directly target Smo, blocks the proliferation of cerebellar granule neuron precursors expressing an oncogenic form of Smo; disrupts spindle pole assembly and kinetochore-microtubule attachment, inhibits melanosome aggregation and peroxisome motility in cultured cells; inhibits AAA+ ATPase motor cytoplasmic dynein.
Product Specifications
CAS Number
302803-72-1
Product Name Alternative
HPI-4 | HH pathway inhibitor 4
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 34 mg/mL
Smiles
N#C/C (C (C1=CC=C (Cl) C=C1Cl) =O) =C (N2) /NC3=C (C=CC=C3) C2=O
Molecular Formula
C17H9Cl2N3O2
Molecular Weight
358.1783
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenepropanenitrile, 2,4-dichloro-α- (3,4-dihydro-4-oxo-2 (1H) -quinazolinylidene) -β-oxo-
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