TAK-715
A potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM; displays >20-fold selectvity over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1; inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM; exerts significant efficacy in rat adjuvant-induced arthritis model.Rheumatoid Arthritis Phase 2 Discontinued.
Product Specifications
CAS Number
303162-79-0
Product Name Alternative
TAK 715 | TAK715
Field of Research
Epigenetics & Chromatin
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=NC=CC (C2=C (C3=CC=CC (C) =C3) N=C (CC) S2) =C1) C4=CC=CC=C4
Molecular Formula
C24H21N3OS
Molecular Weight
399.508
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[4-[2-ethyl-4- (3-methylphenyl) -5-thiazolyl]-2-pyridinyl]-
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